Dynamics and distributions of temperature changes during pharyngeal selective brain cooling by H CSI
نویسندگان
چکیده
D. Coman, H. K. Trubel, P. Herman, and F. Hyder Department of Diagnostic Radiology, Yale University, New Haven, CT, United States, Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States, Bayer HealthCare Research Center, Wuppertal, Germany, Department of Pediatrics, HELIOS-Klinikum Wuppertal, University Witten/Herdecke, Wuppertal, Germany, Semmelweis University, POB 448, H-1446, Budapest, Hungary, Department of Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States
منابع مشابه
Selective brain cooling with endovascular intracarotid infusion of cold saline: a pilot feasibility study.
BACKGROUND AND PURPOSE Endovascular brain cooling as a method for rapid and selective induction of hypothermic neuroprotection has not been systematically studied in humans. In this clinical pilot study we investigated the feasibility, safety, and physiologic responses of short-term brain cooling with IC-CSI. MATERIALS AND METHODS We studied 18 patients (50 +/- 10 years old, 9 women) undergoi...
متن کاملEffects of pharyngeal cooling on brain temperature in primates and humans: a study for proof of principle.
BACKGROUND Pharyngeal cooling decreases brain temperature by cooling carotid arteries. This study was designed to evaluate the principle of pharyngeal cooling in monkeys and humans. METHODS Monkeys (n = 10) were resuscitated following 12 min of cardiac arrest. Pharyngeal cooling (n = 5), in which cold saline (5°C) was perfused into the cuff at the rate of 500 ml/min, was initiated simultaneou...
متن کاملDehydration increases the magnitude of selective brain cooling independently of core temperature in sheep.
By cooling the hypothalamus during hyperthermia, selective brain cooling reduces the drive on evaporative heat loss effectors, in so doing saving body water. To investigate whether selective brain cooling was increased in dehydrated sheep, we measured brain and carotid arterial blood temperatures at 5-min intervals in nine female Dorper sheep (41 +/- 3 kg, means +/- SD). The animals, housed in ...
متن کاملSelective Brain Cooling Reduces Water Turnover in Dehydrated Sheep
In artiodactyls, arterial blood destined for the brain can be cooled through counter-current heat exchange within the cavernous sinus via a process called selective brain cooling. We test the hypothesis that selective brain cooling, which results in lowered hypothalamic temperature, contributes to water conservation in sheep. Nine Dorper sheep, instrumented to provide measurements of carotid bl...
متن کاملMeasurement of human brain temperature changes during cooling
Introduction Therapeutic brain hypothermia is used with increasing frequency as a tool to mitigate neurologic injury [1]. It has been shown that moderate cooling of the brain after hypoxia-ischemia can reduce damage and improve functional outcome [2, 3]. Recently a new method for selective brain cooling was described and prototype device was tested on the pigs [4, 5]. Brain temperature decreasi...
متن کامل